Role of Fas/FasL Pathway-mediated Alveolar Macrophages Releasing Inflammatory Cytokines in Human Silicosis

查看全文 作　　者：YAO San [1,2]Qiao;HE Qin [2]Cheng;YUAN Ju [1]Xiang;CHEN [2]Jie;CHEN [3]Gang;LU [4]Yao;BAI Yu [1]Ping;ZHANG Chun [1]Min;YUAN [3]Yang;XU Ying [1]Jun

机构地区：[1]Department of Occupational and Environmental Health, School of Public Health, Hebei Union University;[2]Division of Pneumoconiosis, School of Public Health, China Medical University;[3]Department of Pneumoconiosis, Beidaihe Sanitarium for China Coal Miners;[4]Department of Community Medicine,Tangshan Workers’ Hospital

出　　处：《Biomedical and Environmental Sciences》索引2013年第26卷第11期,共4页

基　　金：supported by the Natural Science Foundation of China (30671741);the Pneumoconiosis Treatment Foundation for China Coal Miners (2005-03);the Science and Technology Support Program of Hebei Province (09276196D) 摘　　要：The role of Fas/Fas ligand (FasL) in mediating alveolar macrophage (AM)-derived inflammatory cytokines in 29 human lung silicosis patients and 6 controls was studied.It showed that the serum levels of IL-1β,TNF-α,IL-8,MIP-1α,MCP-1,and TGF-β1were higher in silicosis patients than in controls,and increased with the progression of silicosis except TGF-β1 and IL-8.TGF-β1,IL-8,MCP-1,MIP-1αwere efficiently down-regulated by anti-FasL antibody or caspase-8 inhibitor,indicating that Fas/FasL signaling promotes the 关键词：肺泡巨噬细胞 FASL 细胞因子矽肺介导炎症 MCP-1 TGF-β

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Role of Fas/FasL Pathway-mediated Alveolar Macrophages Releasing Inflammatory Cytokines in Human Silicosis

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