Bushen Yisui Capsule ameliorates axonal injury in experimental autoimmune encephalomyelitis

查看全文 作　　者：Ling [1]Fang;Qi [1]Zheng;Tao [2]Yang;Hui [1]Zhao;Qiuxia [1]Zhang;Kangning [2]Li;Li [2]Zhou;Haiyang [2]Gong;Yongping [2]Fan;Lei [1]Wang

机构地区：[1]School of Traditional Chinese Medicine, Capital Medical University;[2]Beijing Tiantan Hospital, Capital Medical University

出　　处：《Neural Regeneration Research》索引2013年第8卷第35期,共10页

基　　金：supported by the National Natural Science Foundation of China,No.81072765,81173237,81273742;Scientific Research Key Project of Beijing Municipal Commission of Education,No.KZ201310025023;Special Fund for Capital Traditional Chinese Medicine and Nursing Research,No.12ZYH01 摘　　要：A preliminary clinical study by our group demonstrated Bushen Yisui Capsule(formerly called Erhuang Formula)in combination with conventional therapy is an effective prescription for the treatment of multiple sclerosis.However,its effect on axonal injury during early multiple sclerosis remains unclear.In this study,a MOG35–55-immunized C57BL/6 mouse model of experimental autoimmune encephalomyelitis was intragastrically administered Bushen Yisui Capsule.The results showed that Bushen Yisui Capsule effectively improved clinical symptoms and neurological function of experimental autoimmune encephalomyelitis.In addition,amyloid precursor protein expression was down-regulated and microtubule-associated protein 2 was up-regulated.Experimental findings indicate that the disease-preventive mechanism of Bushen Yisui Capsule in experimental autoimmune encephalomyelitis was mediated by amelioration of axonal damage and promotion of regeneration.But the effects of the high-dose Bushen Yisui Capsule group was not better than that of the medium-dose and low-dose Bushen Yisui Capsule group in preventing neurological dysfunction. 关键词：自身免疫性脑脊髓炎实验性胶囊补肾损伤多发性硬化轴

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Bushen Yisui Capsule ameliorates axonal injury in experimental autoimmune encephalomyelitis

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