Extracellular matrix synthesis in vascular disease:hypertension,and atherosclerosis

查看全文 作　　者：Markella [1]Ponticos;Barbara [2]D.Smith

机构地区：[1]Centre for Rheumatology & Connective Tissue Diseases,Division of Medicine-Inflammation,Royal Free & University College Medical School,University College London;[2]Department of Biochemistry,Boston University School of Medicine

出　　处：《The Journal of Biomedical Research》索引2014年第28卷第1期,共15页

摘　　要：Extracellular matrix(ECM) within the vascular network provides both a structural and regulatory role.The ECM is a dynamic composite of multiple proteins that form structures connecting cells within the network.Blood vessels are distended by blood pressure and,therefore,require ECM components with elasticity yet with enough tensile strength to resist rupture.The ECM is involved in conducting mechanical signals to cells.Most importantly,ECM regulates cellular function through chemical signaling by controlling activation and bioavailability of the growth factors.Cells respond to ECM by remodeling their microenvironment which becomes dysregulated in vascular diseases such hypertension,restenosis and atherosclerosis.This review examines the cellular and ECM components of vessels,with specific emphasis on the regulation of collagen type I and implications in vascular disease. 关键词：细胞外基质动脉粥样硬化血管疾病高血压合成细胞结构生物利用度 ECM

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Extracellular matrix synthesis in vascular disease:hypertension,and atherosclerosis

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