ABO sequence analysis in an AB type with anti-B patient

查看全文 作　　者：Chen Qing Xiao Jianyu Wang Shuya Li Jiahuang Du Leilei Lu Le Huang Chengyin Li Min Li [1,2]Ping

机构地区：[1]Jiangsu Province Blood Center, Nanjing, Jiangsu 210042, China;[2]Soochow University, Suzhou, Jiangsu 215007, China;

出　　处：《Chinese Medical Journal》索引2014年第5期,共2页

摘　　要：ABO blood group system is the first to be discovered and the most clinically important in transfusion medicine.1The ABO gene encodes a glycosyltransferase which synthesize the oligosaccharide epitopes.The difference between the consensus A gene (A101 allele) usually used as the reference and the consensus B gene (B101 allele) are 7 in-frame single nucleotide polymorphisms (SNPs),among which only 4 alleles cause amino acid mutations in the enzyme.When A allele was inherited from one parent and B allele was inherited from the other which produced the AB blood group,this is known as trans-AB.Cis-AB is characterized as mutant ABO alleles encoding a glycosyltransferase capable of synthesizing both A and B antigens which is very rare. 关键词：序列分析 ABO血型系统 AB型糖基转移酶单核苷酸多态性等位基因患者基因编码

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ABO sequence analysis in an AB type with anti-B patient

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