Two Sets of Acupoint Combination of Similar Functions Engage Shared Neural Representation:A Functional Magnetic Resonance Imaging Study

查看全文 作　　者：[1]赵凌;[2]秦伟;[2]刘继欣;[3]方莉;[2]董明皓;[4]张富文;[1]蒋萃;[2]孙金铂;Karen.M.von [2]Deneen;[1]梁繁荣

机构地区：[1]College of Acupuncture and Tuina,Chengdu University of Traditional Chinese Medicine;[2]Life Sciences Research Center,School of Life Sciences and Technology,Xidian University;[3]The Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine;[4]The Teaching Hospital of Chengdu University of Traditional Chinese Medicine

出　　处：《Chinese Journal of Integrative Medicine》索引2014年第20卷第3期,共10页

基　　金：Supported by the Project for the National Basic Research Program of China(973 Program,No.2012CB518501);the National Natural Science Foundation of China(No.30901900,30930112,and 81101108);the Project of Administration of Traditional Chinese Medicine of Sichuan Province(No.2012-E-038);the Project of Innovative Research Team Research Fund of Sichuan Provincial Education Department(No.12TD002) 摘　　要：Objective:To investigate whether the neural representations underlying alternating two acupoint combinations(ACs) are the same or not.Methods:In this functional magnetic resonance imaging study,two sets of analgesia ACs were utilized,including Waiguan(TE5) and Qiuxu(GB40) for Group A,and Neiguan(PC6)and Taichong(LR3) for Group B,which are the most commonly adopted in clinical treatment.Each group had20 healthy subjects.An experimental design was proposed,which consisted of a pre-needling resting phase,a needling phase and a post-needling resting phase.This paradigm optimally mimics the clinical protocol as well as focuses on both the stimulation and the resting periods.The results were subjected to general linear model analysis,conjunction analysis and the functional connectivity analysis.Results:The rostral anterior cingulated cortex was engaged in the initiative period of the acupuncture effect in both groups,and it was chosen as the seed region for the functional connectivity analysis for the following resting period.The results showed that several shared brain regions were involved in both groups,in particular the insula,amygdala and hypothalamus.Moreover,significant differences were located at the posterior cingulated cortex as revealed by a two sample t-test(P<0.05,corrected).Other regions showed no significant differences.This finding was further supported by the spatial correlation analysis that the two groups were significantly correlated(r=0.51,P<0.01).Conclusion:This preliminary research helps us understand the neurophysiological mechanisms of acupuncture when following clinical guidelines on ACs,as well as provides an important opportunity to develop better treatment strategies for reducing,or even preventing pain. 关键词：功能性磁共振成像神经表征共享穴位功能磁共振成像临床治疗针刺效应

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Two Sets of Acupoint Combination of Similar Functions Engage Shared Neural Representation:A Functional Magnetic Resonance Imaging Study

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