Design,synthesis and antifungal activity of carbazole derivatives

查看全文 作　　者：Shi-Ping [1]Zhu;Wen-Ya [1]Wang;Kun [1]Fang;Zheng-Gang [1]Li;Guo-Qiang [1]Dong;Zhen-Yuan [1]Miao;Jian-Zhong [1]Yao;Wan-Nian [1]Zhang;Chun-Quan [1]Sheng

机构地区：[1]School of Pharmacy,Second Military Medical University

出　　处：《Chinese Chemical Letters》索引2014年第25卷第2期,共5页

基　　金：supported in part by the National Natural Science Foundation of China(No.81222044);the 863 Hi-Tech Program of China(No.2012AA020302);Shanghai Rising-Star Program(No.12QH1402600);Shanghai Municipal Health Bureau(No.XYQ2011038) 摘　　要：The incidence of invasive fungal infections is increasing rapidly.Clinically available antifungal agents suffer from limited efficacy and severe resistance.There is an urgent need to discover antifungal lead compounds with novel chemical scaffold.On the basis of our previously identified tetrahydrocarbazole antifungal leads,the structure-activity relationship was further explored by modifying the scaffold and the side chains.Several targeted compounds showed potent activity against Candida species.Particularly,compound 13i showed better antifungal activity than the lead compound,which can be used as a good starting point for further optimization. 关键词：抗真菌活性咔唑衍生物先导化合物设计合成真菌感染抗真菌剂构效关系

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Design,synthesis and antifungal activity of carbazole derivatives

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