Ginsenoside Rb1 attenuates activated microglia-induced neuronal damage

查看全文 作　　者：Lining [1]Ke;Wei [2]Guo;Jianwen [2]Xu;Guodong [1]Zhang;Wei [2]Wang;Wenhua [1]Huang

机构地区：[1]Department of Human Anatomy, Histology and Embryology, Southern Medical University;[2]Department of Human Anatomy, Histology and Embryology, Fujian Medical University

出　　处：《Neural Regeneration Research》索引2014年第9卷第3期,共8页

基　　金：the National Natural Science Foundation of China,No.81041054;China Postdoctoral Science Foundation funded project(General Program),No.2013M542193 摘　　要：The microglia-mediated inflammatory reaction promotes neuronal damage under cerebral ischemia/hypoxia conditions. We therefore speculated that inhibition of hypoxia-induced microglial activation may alleviate neuronal damage. To test this hypothesis, we co-cultured ginsenoside Rb1, an active component of ginseng, and cortical neurons. Ginsenoside Rb1 protected neuronal morphology and structure in a single hypoxic culture system and in a hypoxic co-culture system with microglia, and reduced neuronal apoptosis and caspase-3 production. The protective effect was observable prior to placing in co-culture. Additionally, ginsenoside Rb1 inhibited levels of tumor necrosis factor-α in a co-culture system containing activated N9 microglial cells. Ginsenoside Rb1 also significantly decreased nitric oxide and superoxide production induced by N9 microglia. Our findings indicate that ginsenoside Rb1 attenuates damage to cerebral cortex neurons by downregulation of nitric oxide, superoxide, and tumor necrosis factor-α expression in hypoxia-activated microglia. 关键词：小胶质细胞神经元损伤人参皂苷 RB 诱导激活衰减肿瘤坏死因子-Α

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Ginsenoside Rb1 attenuates activated microglia-induced neuronal damage

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