Evaluation of the biological toxicity of fluorine in Antarctic krill

查看全文 作　　者：ZHANG [1,2]Ling;LU [1,2]Xiaoqi;WANG [1,2]Zhangmin;QIN [3]Liqiang;LIN [4]Zhiqin;YUAN [2]Linxi;ZHANG [5]Wen;YIN [1,2]Xuebin

机构地区：[1]School of Earth and Space Science,University of Science and Technology of China;[2]Suzhou Key Lab for Eco-safety and Human Health,Suzhou Institute for Advanced Study,University of Science and Technology of China;[3]Department of Nutrition and Food Hygiene,School of Public Health,Soochow University;[4]Environmental Sciences Program,Southern Illinois University;[5]Department of Orthopedics Research Institute,Soochow University

出　　处：《Advances in Polar Science》索引2014年第25卷第1期,共8页

基　　金：the financial support of the Open Research Fund from the Key Laboratory for Polar Science,State Oceanic Administration,P.R.China(Grant no.KP201106);the Research Industry Joint Innovation Project of Jiangsu(Grant no.BY2011186) 摘　　要：Antarctic krill is a potentially nutritious food source for humans, but fluorine(F) toxicity is a matter of concern. To evaluate the toxicity of F in Antarctic krill, 30 Wistar rats were divided into three groups with different dietary regimens: a control group, a krill treatment group(150 mg·kg-1 F), and a sodium fluoride(NaF) treatment group(150 mg·kg-1 F). After three months, F concentrations in feces, plasma, and bone were determined, and the degree of dental and skeletal fluorosis was assessed. The F concentrations in plasma and bone from the krill treatment group were 0.167 0±0.020 4 mg.L-1 and 2 709.8±301.9 mg·kg-1, respectively, compared with 0.043 8±0.005 5 mg·L-1 and 442.4±60.7 mg·kg-1, respectively, in samples from the control group. Concentrations of F in plasma and bone in the krill treatment group were higher than in the control group, but lower than in the NaF treatment group. The degree of dental fluorosis in the krill treatment group was moderate, compared with severe in the NaF treatment group and normal in the control group. The degree of skeletal fluorosis did not change significantly in any group. These results showed that the toxicity of F in Antarctic krill was lower than for an equivalent concentration of F in NaF, but it was toxic for rats consuming krill in large quantities. To conclude, we discuss possible reasons for the reduced toxicity of F in Antarctic krill. The present study provides a direct toxicological reference for the consideration of Antarctic krill for human consumption. 关键词：南极磷虾生物毒性 WISTAR大鼠评价对照组浓度比氟化钠食物来源

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Evaluation of the biological toxicity of fluorine in Antarctic krill

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