Acrolein as a novel therapeutic target for motor and sensory deficits in spinal cord injury

查看全文 作　　者：Jonghyuck [1,2]Park;Breanne [2]Muratori;Riyi [1,2]Shi

机构地区：[1]Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University;[2]Weldon School of Biomedical Engineering, Purdue University

出　　处：《Neural Regeneration Research》索引2014年第9卷第7期,共7页

摘　　要：In the hours to weeks following traumatic spinal cord injuries(SCI), biochemical processes are initiated that further damage the tissue within and surrounding the initial injury site: a process termed secondary injury. Acrolein, a highly reactive unsaturated aldehyde, has been shown to play a major role in the secondary injury by contributing significantly to both motor and sensory deficits. In particular, efforts have been made to elucidate the mechanisms of acrolein-mediated damage at the cellular level and the resulting paralysis and neuropathic pain. In this review, we will highlight the recent developments in the understanding of the mechanisms of acrolein in motor and sensory dysfunction in animal models of SCI. We will also discuss the therapeutic benefits of using acrolein scavengers to attenuate acrolein-mediated neuronal damage following SCI. 关键词：脊髓损伤丙烯醛运动神经元损伤靶标治疗损伤部位生化过程

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Acrolein as a novel therapeutic target for motor and sensory deficits in spinal cord injury

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