Spectrum-Effect Relationship Between High Performance Liquid Chromatography Fingerprints and Anticoccidial Activities of a Compound Chinese Medicine

查看全文 作　　者：XIAO [1]Sui;FEI Chen-[1]zhong;ZHANG Li-[1]fang;ZHENG Wen-[1]li;ZHANG Ke-[1]yu;XUE Fei-[1]qun

机构地区：[1]Key Laboratory of Veterinary Drug Safety Evaluation and Residues Research,Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences

出　　处：《Journal of Integrative Agriculture》索引2014年第13卷第5期,共8页

基　　金：funded by the National Key Technology R&D Program, China (2008 BADB4B05-02) 摘　　要：Quality control and screening of active substances in traditional Chinese medicines have been performed using fi ngerprint analysis. The spectrum-effect relationship between chromatography fi ngerprints and effi cacy of herbal drugs is considered as a potentially useful method for determining active ingredients in complex mixtures. The study was designed to develop a method for determining the bioactive components of a compound Chinese medicine called Tiefeng based on spectrum-effect relationships between high-performance liquid chromatography(HPLC) fi ngerprints and anticoccidial activities. Four peaks of the established HPLC fi ngerprint indicate the main bioactive components of this medicine. In addition, pharmacodynamic atlas was defi ned and used to assess the anticoccidial activity of Tiefeng from different sources for the fi rst time. We found that the level of anticoccidial activity of Tiefeng was consistent with the degree of similarity between the pharmacodynamic atlas and chromatogram of any sample. Furthermore, effect of this medicine was related with the main active constituents, along with the origin and the harvesting time. 关键词：色谱指纹图谱高效液相色谱法活性物质中国医药抗球虫光谱效应 HPLC指纹图谱生物活性成分

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Spectrum-Effect Relationship Between High Performance Liquid Chromatography Fingerprints and Anticoccidial Activities of a Compound Chinese Medicine

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