Quantification of the stiffness and strength of cadherin ectodomain binding with different ions

查看全文 作　　者：Zhiyang [1]Xu;Dechang [1]Li;Baohua [1]Ji

机构地区：[1]Biomechanics and Biomaterials Laboratory, Department of Applied Mechanics,Beijing Institute of Technology

出　　处：《Theoretical & Applied Mechanics Letters》索引2014年第4卷第3期,共6页

基　　金：supported by the National Natural Science Foundation of China(11025208,11221202,11372042,and 11202026);the Excellent Young Scholars Research Fund of Beijing Institute of Technology 摘　　要：The stiffness and strength of extracellular(EC) region of cadherin are proposed to be two important mechanical properties both for cadherin as a mechanotransductor and for the formation of cell-cell adhesion. In this study,we quantitatively characterized the stiffness and strength of EC structure when it binds with different types of ions by molecular dynamics simulations. Results show that EC structure exhibits a rod-like shape with high stiffness and strength when it binds with the bivalent ions of calcium or magnesium. However,it switches to a soft and collapsed conformation when it binds with the monovalent ions of sodium or potassium. This study sheds light on the important role of the bivalent ions of calcium in the physiological function of EC. 关键词：二价离子钙粘蛋白强度刚度分子动力学模拟量化外域细胞粘连

相关文献

参考文献（31）
引证文献（3）
耦合文献（9）

参考文献(31)

引证文献(3)

耦合文献(9)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Quantification of the stiffness and strength of cadherin ectodomain binding with different ions

参考文献(31)

引证文献(3)

耦合文献(9)

用户提示