Synthesis of β-Cyclodextrin-[60]fullerene Conjugate and Its DNA Cleavage Performance

查看全文 作　　者：Jingjing [1,2]Wang;Zhaoheng [1]Zhang;Wei Wu[1,*];Xiqun Jiang[1,*] 机构地区：[1]Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210093, China;[2]College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China;Email: Wei Wu (wuwei@nju.edu.cn), Xiqun Jiang (jiangx@nju.edu.cn)[*]Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210093, China, Tel.: 0086-025-83597138 出　　处：《Chinese Journal of Chemistry》索引2014年第32卷第1期,共7页 基　　金：This study was supported by the Natural Science Foundation of China (Nos.51033002 and 51273090)and the Natural Science Foundation of Jiangsu Province (No.BK2010303). 摘　　要：水可溶的 -cyclodextrin (-CD) functionalized [60 ] fullerene (C60CD ) 被综合。反应的氧种类(ROS ) 的 C60-CD-induced 产生,和 DNA 劈开能力和 C60CD 的 cytotoxicity 在可见轻照耀之上被学习,证明混合物在光力学的治疗的应用是很有希望的。组织学的分析证明 C60CD 没有尖锐或稍尖的毒性到生活身体。 关 键 词：FULLERENE Β-CYCLODEXTRIN DNA-cleavage photodynamic THERAPY