Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

查看全文 作　　者：Ruiting [1]Han;Junli [1]Ma;Houkai [1]Li

机构地区：[1]Functional Metabolomic and Gut Microbiome Laboratory,Institute of Interdisciplinary Integrative Biomedical Research,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China

出　　处：《Frontiers of Medicine》索引2018年第12卷第6期,共13页

基　　金：National Natural Science Foundation of China (No.81673662); The Program for Professor of Special Appointment (Eastern Scholar);Shuguang Scholar (No. 16SG36);Shanghai Institutions of Higher Learning from Shanghai Municipal Education Commission. 摘　　要：Non-alcoholic fatty liver disease (NAFLD)is one of the most common metabolic diseases currently in the context of obesity worldwide,which contains a spectrum of chronic liver diseases,including hepatic steatosis, non-alcoholic steatohepatitis and hepatic carcinoma.In addition to the classical 'Two-hit'theory,NAFLD has been recognized as a typical gut microbiota-related disease because of the intricate role of gut microbiota in maintaining human health and disease formation.Moreover,gut microbiota is even regarded as a 'metabolic organ'that play complementary roles to that of liver in many aspects.The mechanisms underlying gut microbiota-mediated development of NAFLD include modulation of host energy metabolism,insulin sensitivity, and bile acid and choline metabolism.As a result,gut microbiota have been emerging as a novel therapeutic target for NAFLD by manipulating it in various ways,including probiotics,prebiotics,synbiotics,antibiotics,fecal microbiota transplantation,and herbal components.In this review,we summarized the most recent advances in gut microbiota-mediated mechanisms,as well as gut microbiota-targeted therapies on NAFLD. 关键词：gut MICROBIOTA NAFLD obesity insulin resistance BILE ACIDS probiotic

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Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

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