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Orthostatic hypotension,an often-neglected problem in community-dwelling older people:discrepancies between studies and real life

查看全文 作　　者：Sarah [1,2]Damanti;Dario [3]Consormi;Annalisa [4]Valentini;Benedetta [4]Cerasoli;Martina [4]Biotto;Federica [4]Conti;Marta [4]Clerici;Pasqualina [4]Iannuzzi;Emanuela [4]Manzo;Paolo D [1]Rossi;Simona [1]Ciccone;Matteo [1,2]Cesari 高影响力作者 机构地区：[1]Geriatric Unit,Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico,Milan,ltaly;[2]Department of Clinical Sciences and Community Health,University of Milan,Milan,Italy;[3]Unit of Epidemiology,Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico,Milan,ltaly;[4]Fellowship in Geriatrics and Gerontology,University of Milan,Milan,Italy高影响力机构 出　　处：《Journal of Geriatric Cardiology》索引2018年第15卷第10期,共3页高影响力期刊 摘　　要：Orthostatic hypotension (OH)is a common condition in older persons.According to the 2011criteria,OH is defined by a sustained reduction of systolic blood pressure of 20 mmHg or a 10mmHg-fall of diastolic blood pressure,[1] Its prevalence increases with age and according to a recent systematic review the pooled prevalence in community dwelling older people is 22.2%.[2]Although OH is largely explained by concurrent clinical conditions (in particular, hypertension,diabetes,malnutrition,vascular encephalopa- thy,anemia,Parkinson's disease)[3],aging per se determines a series of physiological dysfunctions potentially representing its biological substratum (e.g.,reduction in barore- flex-mediated cardiovascular function,altered salt and water balance at renal level,impaired cardiac diastolic filling).It is also noteworthy that age-related changes in pharmacokinetic and pharmacodynamic mechanisms of drugs (especially in the context of polypharmacy)also increase the risk of OH. 关 键 词：Elderly ORTHOSTATIC HYPOTENSION Prevalence Real-life
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