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The Effects of Secondary Pneumonia on the Curative Efficacy of Multidrug-resistant Tuberculosis: A Retrospective Cohort Study

查看全文 作　　者：TAN Shou [1]Yong;LIANG Zhuo [2]Zhi;Gift [3,4]Chiwala;KUANG Hao [1]Bin;HUANG Zhi [2]Pei;QIN Hong [1]Juan;LI [1]Yan;LI Yan [1]Qiong;H.M.Adnan [3,4]Hameed;ZHANG Tian [3,4]Yu 高影响力作者 机构地区：[1]State Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, Guangzhou 510095, Guangdong, China;[2]School of Public Health, Sun Yat-sen University, Guangzhou 510080, Guangdong, China;[3]State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, Guangdong, China;[4]University of Chinese Academy of Sciences, Beijing 100049, China高影响力机构 出　　处：《Biomedical and Environmental Sciences》索引2018年第31卷第12期,共5页高影响力期刊 基　　金：supported by Guangzhou Municipal Industry and Research Collaborative Innovation Program [201508020248,201604020019];Guangzhou Municipal Clinical Medical Center Program [155700012];partially by the Key Project Grant [SKLRD2016ZJ003] from the State Key Lab of Respiratory Disease,Guangzhou Institute of Respiratory Diseases;Science and Technology Innovation Leader of Guangdong Province [2016TX03R095,to TZ];by the UCAS Fellowship Program(to H.M.A.H);by the CAS-TWAS President’s Fellowship(to G.C) 摘　　要：Tuberculosis (TB) is a formidable global health problem and ranks above HIV as the leading cause of death worldwide. In 2017, a total number of 10.0 million cases of TB were reported, which resulted in 1.3 million TB deaths. Resistance to standard anti-TB drugs poses a major threat to control of TB, and 450, 000 cases of multidrug-resistant TB (MDR-TB) were estimated in 2017, which indicates the severity of the problem[1]. Pneumonia is one of the common infectious diseases that cause morbidity and mortality in China, causing approximately 2.5 million new cases and 125, 000 deaths annually[2]. Particularly, a high risk of pneumonia in TB was observed among patients with TB compared to that in the general population[3]. Regarding patients with MDR-TB, the extensive for the focus of lung[4] and lung dysbacteriosis[5] further increase the risk of secondary pneumonia, and the role of secondary pneumonia in the efficacy of anti-TB treatment needs to be delineated. 关 键 词：TUBERCULOSIS (TB) SECONDARY PNEUMONIA EFFECTS
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