Neuroprotective effect of ischemic preconditioning in focal cerebral infarction: relationship with upregulation of vascular endothelial growth factor

查看全文 作　　者：Yong [1,2]Liu;Suiqiang [1]Zhu;Yunfu [2]Wang;Jingquan [2]Hu;Lili [2]Xu;Li [2]Ding;Guangjian [2]Liu

机构地区：[1]Department of Neurology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology;[2]Department of Neurology, Taihe Hospital Affiliated to Hubei University of Medicine

出　　处：《Neural Regeneration Research》索引2014年第9卷第11期,共5页

摘　　要：Neuroprotection by ischemic preconditioning has been confirmed by many studies, but the precise mechanism remains unclear. In the present study, we performed cerebral ischemic preconditioning in rats by simulating a transient ischemic attack twice(each a 20-minute occlusion of the middle cerebral artery) before inducing focal cerebral infarction(2 hour occlusion-reperfusion in the same artery). We also explored the mechanism underlying the neuroprotective effect of ischemic preconditioning. Seven days after occlusion-reperfusion, tetrazolium chloride staining and immunohistochemistry revealed that the infarct volume was significantly smaller in the group that underwent preconditioning than in the model group. Furthermore, vascular endothelial growth factor immunoreactivity was considerably greater in the hippocampal CA3 region of preconditioned rats than model rats. Our results suggest that the protective effects of ischemic preconditioning on focal cerebral infarction are associated with upregulation of vascular endothelial growth factor. 关键词：血管内皮细胞生长因子神经保护作用缺血预处理因子表大脑海马CA3区免疫反应性免疫组化

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Neuroprotective effect of ischemic preconditioning in focal cerebral infarction: relationship with upregulation of vascular endothelial growth factor

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