Notch signaling in blood vessels: from morphogenesis to homeostasis

查看全文 作　　者：ZHANG [1]Ping;YAN [1]XianChun;CHEN [1,2]Yan;YANG [1]ZiYan;HAN [1]Hua

机构地区：[1]Department of Medical Genetics and Developmental Biology,Xijing Hospital,Fourth Military Medical University;[2]Department of Oncology,Xijing Hospital,Fourth Military Medical University

出　　处：《Science China(Life Sciences)》索引2014年第57卷第8期,共7页

基　　金：supported by the National Natural Science Foundation of China(91339115,31370769,30830067) 摘　　要：Notch signaling is an evolutionarily conserved intercellular signaling pathway that plays numerous crucial roles in vascular development and physiology.Compelling evidence indicates that Notch signaling is vital for vascular morphogenesis including arterial and venous differentiation and endothelial tip and stalk cell specification during sprouting angiogenesis and also vessel maturation featured by mural cell differentiation and recruitment.Notch signaling is also required for vascular homeostasis in adults by keeping quiescent phalanx cells from re-entering cell cycle and by modulating the behavior of endothelial progenitor cells.We will summarize recent advances of Notch pathway in vascular biology with special emphasis on the underlying molecular mechanisms. 关键词：信号传导途径血管发育形态 NOTCH 平衡槽口细胞分化内皮祖细胞

相关文献

参考文献（80）
引证文献（15）
耦合文献（0）

参考文献(80)

引证文献(15)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Notch signaling in blood vessels: from morphogenesis to homeostasis

参考文献(80)

引证文献(15)

用户提示