Imbalance and dysfunction of transient receptor potential channels contribute to the pathogenesis of hypertension

查看全文 作　　者：LIU [1]DaoYan;XIONG [1]ShiQiang;ZHU [1]ZhiMing

机构地区：[1]Center for Hypertension and Metabolic Diseases,Department of Hypertension and Endocrinology,Daping Hospital,Third Military Medical University,Chongqing Institute of Hypertension

出　　处：《Science China(Life Sciences)》索引2014年第57卷第8期,共8页

摘　　要：Intracellular Ca2+homeostasis is essential for vascular function and blood pressure regulation.Because of their unique roles in regulating intracellular Ca2+concentration and vascular function,a novel class of non-selective cation channels,called transient receptor potential(TRP)channels,have emerged at the frontier of hypertension research.Based on their role in vasculature function regulation,TRP channels can be divided into two functional subtypes:one that participates in vasoconstriction and one that participates in vasodilatation.A functional imbalance of these two subtypes of TRP channels may disturb intracellular calcium([Ca2+]i)homeostasis,and the consequent vascular dysfunction may contribute to the development of hypertension.The potential of these TRP channels as novel pharmacological targets for the treatment of human hypertension is of great interest. 关键词：非选择性阳离子通道高血压发病机制电位受体瞬时血管功能异常

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Imbalance and dysfunction of transient receptor potential channels contribute to the pathogenesis of hypertension

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