Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma

查看全文 作　　者：Deshui [1,2]Jia;Ying [1,2]Jing;Zhenfeng [1]Zhang;Li [1]Liu;Jie [1]Ding;Fangyu [1]Zhao;Chao [1]Ge;Qifeng [3]Wang;Taoyang [4]Chen;Ming [1]Yao;Jinjun [1]Li;Jianren [1]Gu;Xianghuo [1]He 机构地区：[1]State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai diao Tong University School of Medicine, Shanghai 200032, China;[2]Shanghai Medical College, Fudan University, Shanghai 200032, China;[3]Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai 200032, China;[4]Qidong Liver Cancer Institute, Qidong, Jiangsu 226200, China 出　　处：《Cell Research》索引2014年第24卷第2期,共14页 基　　金：We are very grateful to professor Didier Trono (Ecole Polytechnique F6d6rale de Lausanne, 1015 Lausanne, Switzerland) for providing the pWPXL, psPAX2 and pMD2.G lentivirus plasmids. This work was partially supported by the National Key Basic Research Program of China (2013CB910500), the National Natural Science Foundation of China (81125016, 81071637 and 91029728), Shanghai Science and Technology Commission (11XD1404500), Shanghai Municipal Education Commission and Shanghai Munici- pal Health Bureau (llSG18 and XBR2011039). 摘　　要：我们以前在 hepatocellular 癌(HCC ) 识别了体的拷贝数字改变(CNA ) 的 1 241 个区域。在现在的学习,我们发现那新奇周期性的焦点的 amplicon, 1q24.1-24.2,在 HCC 指向 MPZL1 基因。尤其是,在 MPZL1 和 HCC 标本的 intrahepatic 转移的表示层次之间有积极关联。MPZL1 能显著地提高 HCC 房间的迁移、变形的潜力。而且,我们发现 MPZL1 由支持 HCC 房间移植的机制之一由导致支持 metastatic 蛋白质的 phosphorylation 和激活, cortactin。另外,我们发现 Src kinase 调停 cortactin 的 phosphorylation 和激活由 MPZL1 overexpression 导致了。一起拿,这些调查结果建议 MPZL1 是拷贝数字扩大的一个周期性的区域在 HCC 目标为 1q24.1-24.2 的新奇支持 metastatic 基因。 关 键 词：肝癌细胞 蛋白激酶 细胞迁移 磷酸化 肿瘤细胞 皮层 介导 化促