Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats

查看全文 作　　者：Bin [1]Liu;Jing [1]Tang;Jinxia [1]Zhang;Shiying [1]Li;Min [1]Yuan;Ruimin [1]Wang

机构地区：[1]First Department of Neurology, the Affiliated Hospital of Hebei United University

出　　处：《Neural Regeneration Research》索引2014年第9卷第13期,共9页

基　　金：supported by the Scientific Technology Research Project of Hebei Provincial Higher Learning Schools in China,No.ZH2012046;the Major Medical Research Program of Hebei Province in China,No.ZD2013087 摘　　要：It remains unclear whether autophagy affects hippocampal neuronal injury in vascular dementia. In the present study, we investigated the effects of autophagy blockade on hippocampal neuronal injury in a rat model of vascular dementia. In model rats, hippocampal CA1 neurons were severely damaged, and expression of the autophagy-related proteins beclin-1, cathepsin B and microtubule-associated protein 1 light chain 3 was elevated compared with that in sham-operated animals. These responses were suppressed in animals that received a single intraperitoneal injection of wortmannin, an autophagy inhibitor, prior to model establishment. The present results confirm that autophagy and autophagy-related proteins are involved in the pathological changes of vascular dementia, and that inhibition of autophagy has neuroprotective effects. 关键词：血管性痴呆海马神经元大鼠模型神经元损伤自噬微管相关蛋白活化组织蛋白酶B

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Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats

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