Clinico-pathological significance of extra-nodal spread in special types of breast cancer

查看全文 作　　者：Ecmel Isik [1]KaygusuzH;Handan [1]Cetiner;Hulya [1]Yavuz

机构地区：[1]Department of Pathology, Zeynep Kamil Maternity and Children's Training and Research Hospital

出　　处：《Cancer Biology & Medicine》索引2014年第11卷第2期,共7页

摘　　要：Objective: To investigate the significance of extra-nodal spread in special histological sub-types of breast cancer and the relationship of such spread with prognostic parameters.Methods: A total of 303 breast cancer cases were classified according to tumor type, and each tumor group was subdivided according to age, tumor diameter, lymph node metastasis, extra-nodal spread, vein invasion in the adjacent soft tissue, distant metastasis, and immunohistochemical characteristics [estrogen receptor(ER), progesterone receptor(PR) existence, p53, c-erbB-2, and proliferative rate(Ki-67)]. The 122 cases with extra-nodal spread were clinically followed up.Results: An extra-nodal spread was observed in 40%(122 cases) of the 303 breast cancer cases. The spread most frequently presented in micro papillary carcinoma histological sub-type(40 cases, 75%), but least frequently presents in mucinous carcinoma(2 cases, 8%). Patients with extra-nodal spread had a high average number of metastatic lymph nodes(8.3) and a high distant metastasis rate(38 cases, 31%) compared with patients without extra-nodal spread.Conclusion: The existence of extra-nodal spread in the examined breast cancer sub-types has predictive value in forecasting the number of metastatic lymph nodes and the disease prognosis. 关键词：临床病理乳腺癌淋巴结类型雌激素受体孕激素受体免疫组化外扩散

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Clinico-pathological significance of extra-nodal spread in special types of breast cancer

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