Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth

查看全文 作　　者：Yuan [1,6]Yin;Xing [1]Cai;Xi [1]Chen;Hongwei [1]Liang;Yujing [1]Zhang;Jing [1]Li;Zuoyun [2]Wang;Xiulan [3]Chen;Wen [1]Zhang;Seiji [4]Yokoyama;Cheng [1]Wang;Liang [1]Li;Limin [1]Li;Dongxia [1]Hou;Lei [1]Dong;Tao [5]Xu;Takachika [4]Hiroi;Fuquan [3]Yang;Hongbin [2]Ji;Junfeng [1]Zhang;Ke [1]Zen;Chen-Yu [1]Zhang

机构地区：[1]Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology (JERC-MBB), State Key Laboratory of Pharmaceutical Bioteehnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu 210093, China;[2]State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China;[3]Key Laboratory of Protein and Peptide Pharmaceuticals & Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;[4]Department of Allergy and Immunology, The Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan;[5]National Laboratory of Biomac-romolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;[6]Wuxi Oncology Institute, the Affiliated Hospital of Jiang Nan University, Wuxi, Jiangsu 214062, China

出　　处：《Cell Research》索引2014年第24卷第10期,共17页

基　　金：We thank ProfAlexander Rudensky (Memorial Sloan-Kettering Cancer Center, New York) for diphtheria toxin-treated Foxp3DrR mice. We thank Drs Zheng-Gang Liu (Cancer Research Institute, NIH) and Dan Wu (Yale University) for their comments on the manuseirpt. This work was supported by grants from the National Basic Research Program of China (973 Program; 2014CB542300), the National Natural Science Foundation of China (81101330, 31271378 and 81250044), the Natural Science Foundation of Jiangsu Province (BK2011013 and BK2012014) and the Research Special Fund for Public Welfare Industry of Health (201302018). This work was also supported by the program for New Century Excellent Talents in University from the Ministry of Education of China (NCET- 12-0261). 关键词：调节性T细胞肿瘤生长细胞分泌免疫逃避诱导反义寡核苷酸 IL-10 EG细胞

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Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth

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