Role of MMP-2 and MMP-9 and their natural inhibitors in liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases

查看全文 作　　者：Jacek [1]Kurzepa;Agnieszka M?[2]dro;Gra?yna [2]Czechowska;Joanna [3]Kurzepa;Krzysztof [2]Celiński;Weronika [2]Kazmierak;Maria S?[2]omka 机构地区：[1]Department of Medical Chemistry, Medical University of Lublin, Chod?ki 4a, Lublin 20-093, Poland;[2]Department of Gastrology, Medical University of Lublin, Jaczweskiego 8, Lublin 20-954, Poland;[3]1st Department of Radiology, University Hospital No. 4, Jaczewskiego 8, Lublin 20-954, Poland 出　　处：《Hepatobiliary & Pancreatic Diseases International》索引2014年第13卷第6期,共10页 基　　金：supported by a grant from own resources of Medical University of Lublin 摘　　要：BACKGROUND: There is a growing evidence that matrix metalloproteinase (MMP)-2 and MMP-9 (gelatinases) play an important role in the pathogenesis of numerous disorders especially with inflammatory etiology and extracellular matrix (ECM) remodeling. Despite the fact that gelatinases involve in liver cirrhosis is provided in the literature, their role in the pathogenesis of chronic pancreatitis and non-specific inflammatory bowel diseases is still under investigation.DATA SOURCES: We carried out a PubM ed search of English language articles relevant to the involvement of gelatinases in the pathogenesis of liver fibrosis, pancreatitis, and non-specific inflammatory bowel diseases.RESULTS: The decreased activity of gelatinases, especially MMP-2, is related to the development of liver fibrosis, probably due to the decrease of capability for ECM remodeling. Similar situation can be found in chronic pancreatitis; however reports on this matter are rare. The presence of non-specific inflammatory bowel diseases results in MMP-9 activity elevation.CONCLUSION: The fluctuation of gelatinases activity during liver fibrosis, chronic pancreatitis and non-specific inflammatorybowel diseases is observed, but the exact role of these enzymes demands further studies. 关 键 词：MMP-9 MMP-2 胰腺炎 肝硬化 疾病 慢性 抑制剂 基质金属蛋白酶