Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines

查看全文 作　　者：Ravichandran [1,2]Senthilkumar;CHEN Bao-[1,2]An;CAI Xiao-[1,2]Hui;FU [3]Rong

机构地区：[1]Department of Neoplastic Hematologic Disorders (Medical Science Key Subject of Jiangsu Province), Zhongda Hospital, Schoool of Medicine, Southeast University;[2]Department of Oncology, School of Medicine, Southeast University;[3]State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University

出　　处：《Chinese Journal of Natural Medicines》索引2014年第12卷第12期,共14页

基　　金：supported by the National Natural Science Foundation of P.R.China(Nos.81170492,81370673);National High Technology Research and Development Program 863 of P.R.China(No.2012AA022703);National Key Basic Research Program 973 of P.R.China(No.2010CB732404);Key Medical Projects of Jiangsu Province(No.BL2014078);Key Discipline of Jiangsu Province(2011-2015) 摘　　要：Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in human cancers. Therefore, it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients. Plant-derived natural products have been used for the treatment of various diseases for thousands of years. This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines. Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds. 关键词：Traditional medicinal plants LEUKEMIA Multidrug resistance(MDR) Reversal multidrug resistance Apoptosis

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Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines

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耦合文献(89)

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