FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

查看全文 作　　者：Xu [1,2]Zhao;Ying [1,2]Yang;Bao-Fa [1]Sun;Yue [1,2]Shi;Xin [1,2]Yang;Wen [1,2]Xiao;Ya-Juan [1,2]Hao;Xiao-Li [1,2]Ping;Yu-Sheng [1,2]Chen;Wen-Jia [1,2]Wang;Kang-Xuan [1,2]Jin;Xing [1,2]Wang;Chun-Min [1]Huang;Yu [3]Fu;Xiao-Meng [1]Ge;Shu-Hui [1]Song;Hyun Seok [4]Jeong;Hiroyuki [5]Yanagisawa;Yamei [6]Niu;Gui-Fang [7]Jia;Wei [3]Wu;Wei-Min [6]Tong;Akimitsu [4,5]Okamoto;Chuan [7,8]He;Jannie M Rendtlew [1,9]Danielsen;Xiu-Jie [10]Wang;Yun-Gui [1]Yang

机构地区：[1]Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Acaemy of Sciences, No. 1-7 Beichen West Road, Chaoyang District, Beijing 100101, China;[2]University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, China;[3]Protein Science Laboratory of the Ministry of Education, School of Life Sciences, Tsinghua University, Qinghuayuan 1, Beijing 100084, China;[4]Research Center for Advanced Science and Technology, the University of Tokyo, 4-6-1 Kom- aba, Meguro-ku, Tokyo 153-8904, Japan;[5]RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan;[6]Department of Pathology, Center for Experimental Animal Research, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China;[7]Department of Chemical Biology, Beijing National Laboratory for Molecular Sciences, Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;[8]Department of Chemistry, Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA;[9]The Novo Nordisk Foundation Center for Protein Research, Ubiquitin Signalling Group, Faculty of Health Sciences, Blegdamsvej 3b, 2200 Copenhagen, Denmark;[10]Key Laboratory of Genetic Network Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

出　　处：《Cell Research》索引2014年第24卷第12期,共17页

关键词：RNA剪接脂肪形成调控因子 FTO 去甲基化相关蛋白基因表达剪接位点

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FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

参考文献(67)

引证文献(139)

耦合文献(363)

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