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Human bone marrow mesenchymal stem cell transplantation attenuates axonal injury in stroke rats

查看全文 作　　者：Yi [1]Xu;Shiwei [2]Du;Xinguang [1]Yu;Xiao [3,4]Han;Jincai [3,4]Hou;Hao [3,4]Guo 高影响力作者 机构地区：[1]Department of Neurosurgery, General Hospital of Chinese PLA;[2]Department of Neurosurgery, General Hospital of Armed Police Forces;[3]Xiyuan Hospital, China Academy of Chinese Medical Sciences, Institute of Basic Medical Sciences;[4]Beijing Key Laboratory of Pharmacology of Chinese Materia Medica, Institute of Basic Medcal Sciences of Xiyuan Hospital高影响力机构 出　　处：《Neural Regeneration Research》索引2014年第9卷第23期,共6页高影响力期刊 摘　　要：Previous studies have shown that transplantation of human bone marrow mesenchymal stem cells promotes neural functional recovery after stroke, but the neurorestorative mechanisms remain largely unknown. We hypothesized that functional recovery of myelinated axons may be one of underlying mechanisms. In this study, an ischemia/reperfusion rat model was established using the middle cerebral artery occlusion method. Rats were used to test the hypothesis that intravenous transplantation of human bone marrow mesenchymal stem cells through the femoral vein could exert neuroprotective effects against cerebral ischemia via a mechanism associated with the ability to attenuate axonal injury. The results of behavioral tests, infarction volume analysis and immunohistochemistry showed that cerebral ischemia caused severe damage to the myelin sheath and axons. After rats were intravenously transplanted with human bone marrow mesenchymal stem cells, the levels of axon and myelin sheath-related proteins, including microtubule-associated protein 2, myelin basic protein, and growth-associated protein 43, were elevated, infarct volume was decreased and neural function was improved in cerebral ischemic rats. These findings suggest that intravenously transplanted human bone marrow mesenchymal stem cells promote neural function. Possible mechanisms underlying these beneficial effects include resistance to demyelination after cerebral ischemia, prevention of axonal degeneration, and promotion of axonal regeneration. 关 键 词：骨髓间充质干细胞 干细胞移植 轴突损伤 大鼠模型 中风 衰减 髓鞘碱性蛋白 神经保护作用
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