Diabetic cardiac autonomic neuropathy: Do we have any treatment perspectives?

查看全文 作　　者：Victoria A [1]Serhiyenko;Alexandr A [1]Serhiyenko

机构地区：[1]Department of Endocrinology,National Medical University named after Danylo Galytski

出　　处：《World Journal of Diabetes》索引2015年第6卷第2期,共14页

摘　　要：Cardiac autonomic neuropathy(CAN) is a serious and common complication of diabetes mellitus(DM). Despite its relationship to an increased risk of cardiovascular mortality and its association with multiple symptoms and impairments, the significance of CAN has not been fully appreciated. CAN among DM patients is characterized review the latest evidence and own data regarding the treatment and the treatment perspectives for diabetic CAN. Lifestyle modification, intensive glycemic control might prevent development or progression of CAN. Pathogenetic treatment of CAN includes: balanced diet and physical activity; optimization of glycemic control; treatment of dyslipoproteinemia; correction of metabolic abnormalities in myocardium; prevention and treatment of thrombosis; use of aldose reductase inhibitors; dihomo-γ-linolenic acid(DGLA), acetyl-Lcarnitine, antioxidants, first of all α-lipoic acid(α-LA), use of long-chain ω-3 and ω-6 polyunsaturated fatty acids(ω-3 and ω-6 PUFAs), vasodilators, fat-soluble vitamin B1, aminoguanidine; substitutive therapy of growth factors, in severe cases-treatment of orthostatic hypotension. The promising methods include research and use of tools that increase blood flow through the vasa vasorum, including prostacyclin analogues, thromboxane A_2 blockers and drugs that contribute into strengthening and/or normalization of Na^+, K^+-ATPase(phosphodiesterase inhibitor), α-LA, DGLA, ω-3 PUFAs, and the simultaneous prescription of α-LA, ω-3 PUFA and DGLA. 关键词：Diabetes MELLITUS CARDIAC autonomicneuropathy POSTURAL HYPOTENSION TREATMENT

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Diabetic cardiac autonomic neuropathy: Do we have any treatment perspectives?

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