Clinical Utility of the Ratio Between Circulating Fibrinogen and Fibrin (ogen) Degradation Products for Evaluating Coronary Artery Disease in Type 2 Diabetic Patients

查看全文 作　　者：Wei-Xin [1,2]Xiong;Ying [1]Shen;Dao-Peng [1,2]Dai;Lin [1,2]Lu;Qi [1]Zhang;Rui-Yan [1]Zhang;Wei-Feng [1,2]Shen;Rong [1]Tao

机构地区：[1]Department of Cardiology, Ruijin Hospital, Jiao Tong University School of Medicine, Shanghai 200025, China;[2]Institute of Cardiovascular Disease, Jiao Tong University School of Medicine, Shanqhai 200025, China

出　　处：《Chinese Medical Journal》索引2015年第6期,共6页

基　　金：the grants from Chinese Natural Science Foundation,Shanghai Science and Technology Key Project 摘　　要：Background: We investigated whether and to what extent the ratio between circulating fibrinogen (Fg) and its degradation products (FDP) reflects the severity of coronary artery disease (CAD) in type 2 diabetic patients. Methods: Plasma levels of Fg and FDP were determined, and Fg/FDP ratio was calculated in 344 consecutive patients with type 2 diabetes and chest pain on exertion undergoing coronary angiography. The severity of CAD was evaluated by the number of significant CAD (〉50% luminal diameter narrowing) and Gensini score. Results: Plasma Fg was higher, but Fg/FDP ratio was lower in patients with significant CAD (n = 255) compared with those without (n = 89), due to a disproportionate increase in FDP. Fg and FDP correlated positively, while Fg/FDP ratio negatively, with the number of diseased coronary arteries and the tertile of Gensini score (all P values for trend 〈 0.01). After adjusting for age, sex, risk factors for CAD, lipid profiles, glycosylated hemoglobin A1 c, creatinine, leukocyte count, and high-sensitivity C-reactive protein, Fg/FDP ratio remained an independent determinant for multivessel coronary disease (MVD) (odds ratio [OR], 0.869; 95% confidence interval [C/], 0.788~).958, P = 0.005) and high tertile of Gensini score (OR, 0.797, 95% CI, 0.682-0.930, P = 0.004). The area under the curve of Fg/FDP ratio was larger than that of Fg for predicting the presence of MVD (0.647 vs. 0.563, P = 0.048) and Gensini score 〉 30 (0.656 vs. 0.538, P = 0.026). Conclusions: Elevated plasma Fg and FDP level and reduced Fg/FDP ratio are associated with presence of CAD, and Fg/FDP ratio is superior to Fg in reflecting severe coronary atherosclerosis for patients with type 2 diabetes. 关键词：CORONARY Artery Disease Diabetes MELLITUS FIBRIN (ogen) Degradation Products FIBRINOGEN

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Clinical Utility of the Ratio Between Circulating Fibrinogen and Fibrin (ogen) Degradation Products for Evaluating Coronary Artery Disease in Type 2 Diabetic Patients

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