Variant TP53BP1 rs560191 G>C is associated with risk of gastric cardia adenocarcinoma in a Chinese Han population

查看全文 作　　者：Sheng [1]Zhang;Weifeng [2]Tang;Guowen [2]Ding;Chao [2]Liu;Ruiping [3]Liu;Suocheng [2]Chen;Haiyong [2]Gu;Chunzhao [1]Yu

机构地区：[1]Department of General Surgery,the Second Affiliated Hospital of Nanjing Medical University;[2]Department of Cardiothoracic Surgery,Affiliated People's Hospital of Jiangsu University;[3]Department of Orthopedics,Affiliated Hospital of Nanjing Medical University,Changzhou Second People's Hospital

出　　处：《Chinese Journal of Cancer Research》索引2015年第27卷第2期,共7页

基　　金：supported in part by National Natural Science Foundation of China(No.81101889) 摘　　要：Objective:To investigate the association between gastric cardia adenocarcinoma(GCA) and ten functional single nucleotide polymorphisms(SNPs),including TP53BP1 rs560191 G>C,CASP8 rsl035142 G>T,CASP7 rs3127075 G>C,CASP7 rs7907S19 C>A,and six C1orf10/CRNN variants.We performed a hospitalbased case-control study to evaluate the genetic effects of these SNPs.Methods:Two hundred and forty-three GCA cases and 476 controls were enrolled in this study.A customby-design 48-Plex SNPscan^(TM) Kit was used to determine their genotypes.Results:When the TP53BP1 rs560191 GG homozygote genotype was used as the reference group,the GC genotype was associated with a significantly increased risk of GCA.The CC genotype was not associated with the risk of GCA compared with the GG genotype.None of the CASP8 rs1035142 G>T,CASP7rs3127075 G>C,CASP7 rs7907519 C>A or the six C1orf10/CRNN polymorphisms showed a significant difference in genotype distributions between the cases and the controls.Conclusions:The results demonstrated that the functional polymorphism TP53BP1 rs560191 G>C might contribute to GCA susceptibility.However,the statistical power of our study was limited.Large,welldesigned stuthes and further functional investigations are needed to confirm our findings. 关键词：中国汉族人群风险单核苷酸多态性变种腺癌 GCA GGT 基因型

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Variant TP53BP1 rs560191 G>C is associated with risk of gastric cardia adenocarcinoma in a Chinese Han population

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