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Potassium dehydroandrographolide succinate injection for treatment of infantile pneumonia:a systematic review and Meta-analysis

查看全文 作　　者：Zhang [1]Xiaomeng;Wu [1]Jiarui;Zhang [1]Bing;Dong [2]Ling 高影响力作者 机构地区：[1]Department of Clinical Pharmacology of Traditional Chinese Medicine,School of Chinese Materia Medica,Beijing University of Chinese Medicine;[2]Department of Pharmaceutics of Chinese Medicine,School of Chinese Materia Medica,Beijing University of Chinese Medicine高影响力机构 出　　处：《Journal of Traditional Chinese Medicine》索引2015年第35卷第2期,共9页高影响力期刊 基　　金：Supported by National Natural Science Foundation of China(Study on the Key Factors of Allergic Reaction That Caused by Chinese Herbal Injection Based on the Three-dimensional Database and Multi-dimensional Data Mining,No.81473547);Scientific Research Innovation Team Project of Beijing University of Chinese Medicine(Research on the Disciplinary of Clinical Pharmacology of Traditional Chinese Medicine,No.2011-CXTD-14);Ministry of Education Research Fund for Doctor Program(No.20130013120001,20120013130002) 摘　　要：OBJECTIVE:To evaluate systematically the clinical efficacy and safety of potassium dehydroandrographolide succinate injection(PDS) in treatment of infantile pneumonia.METHODS:Randomized controlled trials(RCTs) of infantile pneumonia treated by PDS were searched in China National Knowledge Infrastructure Database,China Science and Technology Journal Database,Wanfang Database,Chinese Biomedical Literature Database,PubMed,and Cochrane Library,from January 1979 to July 2013.Two reviewers independently retrieved the RCTs and extracted the information.The quality of included studies was assessed by the Cochrane risk of bias,and a Meta-analysis was conducted with Review Manager 5.2 software.RESULTS:A total of 9 studies with 1056 participants were included.The quality of the studies was generally no high,only one study mentioned the random method.The Meta-analysis indicated that PDS was significantly superior to the conventional therapy in the total effective rate[relative risk(RR)=1.21,95%CI(1.14,1.27),P<0.000 01],the time of temperature recovery[mean difference(MD)=-1.43,95%CI(-1.75,-1.11),P<0.000 01],rale disappeared and cough relieving[MD=-1.44,95%CI(-1.93,-0.90),P<0.000 01].Six adverse drug reactions from five studies mainly represented rash and diarrhea,and no serious ADRs were reported.CONCLUSION:Based on this systematic review,PDS was proved effective and relatively safe in treatment of infantile pneumonia.However the articles enrolled in the study were not high in quality,studies with higher quality should be conducted for assessment of efficacy and safety of PDS in treatment of infantile pneumonia. 关 键 词：综合布线系统 穿琥宁注射液 治疗 肺炎 小儿 随机对照试验 Meta分析 药物不良反应
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