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Human epidermal growth factor receptor 2 expression in mixed gastric carcinoma

查看全文 作　　者：Yang-Kun [1]Wang;Zhong [2]Chen;Tian [1]Yun;Cong-Yang [3]Li;Bo [4]Jiang;Xue-Xia [1]Lv;Guang-Hui [5]Chu;Su-Nan [6]Wang;Hui [5]Yan;Lei-Feng [5]Shi 高影响力作者 机构地区：[1]Department of Pathology, 150~(th) Luoyang Center Hospital;[2]Department of Medicine Genetic, University of Utah School of Medicine;[3]Department of Pathology, 152~(nd) Center Hospital;[4]Department of Pathology, 159~(th) Center Hospital;[5]Department of Gastrointestinal Surgery, 150~(th) Luoyang Center Hospital;[6]Institute of Computer technology, School of Electronics and Communication Engineering高影响力机构 出　　处：《World Journal of Gastroenterology》索引2015年第21卷第15期,共8页高影响力期刊 摘　　要：AIM: To investigate human epidermal growth factor receptor 2(HER2) amplification and protein expression in mixed gastric carcinoma.METHODS: Fluorescence in situ hybridization and immunohistochemistry were used to detect HER2 amplification and protein expression in 277 cases of mixed gastric carcinoma. Protein staining intensity was rate as 1+, 2+, or 3+.RESULTS: Of the 277 cases, 114(41.2%) expressed HER2 protein. HER2 3+ staining was observed in 28/277(10.1%) cases, 2+ in 37/277(13.4%) cases, and 1+ in 49/277(17.7%) cases. A HER2 amplification rate of 17% was detected, of which 25/28(89.3%) were observed in the HER2 3+ staining group, 17/37(45.9%) in 2+, and 5/49(10.2%) in 1+. Of the 47 patients with HER2 amplification who received chemotherapy plus trastuzumab, 22 demonstrated median progression-free and overall survivals of 9.1 mo and 16.7 mo, respectively, which were significantly better than those achieved with chemotherapy alone(5.6 mo and 12.1 mo, respectively) in 19 previously treated patients(P s < 0.05). CONCLUSION: HER2 detection in mixed gastric carcinoma displays high heterogeneity. Relativelyquantitative parameters are needed for assessing the level of HER2 amplification and protein expression. 关 键 词：Fluorescence in SITU HYBRIDIZATION Gastricpathology Human EPIDERMAL growth factor receptor 2 IMMUNOHISTOCHEMISTRY STOMACH
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