Portal vein thrombosis in cirrhosis: Controversies and latest developments

查看全文 作　　者：Damian J [1]Harding;M Thamara PR [1]Perera;Frederick [2]Chen;Simon [3]Olliff;Dhiraj [1]Tripathi

机构地区：[1]Liver Unit, Queen Elizabeth Hospital,Birmingham;[2]Department of Haematology, Queen Elizabeth Hospital,Birmingham;[3]Department of Imaging and Interventional Radiology, Queen Elizabeth Hospital,Birmingham

出　　处：《World Journal of Gastroenterology》索引2015年第21卷第22期,共16页

摘　　要：Portal vein thrombosis(PVT) is encountered in livercirrhosis, particularly in advanced disease. It has been a feared complication of cirrhosis, attributed to significant worsening of liver disease, poorer clinical outcomes and potential inoperability at liver transplantation; also catastrophic events such as acute intestinal ischaemia. Optimal management of PVT has not yet been addressed in any consensus publication.We review current literature on PVT in cirrhosis; its prevalence, pathophysiology, diagnosis, impact on the natural history of cirrhosis and liver transplantation,and management. Studies were identified by a search strategy using MEDLINE and Google Scholar. The incidence of PVT increases with increasing severity of liver disease: less than 1% in well-compensated cirrhosis, 7.4%-16% in advanced cirrhosis. Prevalence in patients undergoing liver transplantation is 5%-16%.PVT frequently regresses instead of uniform thrombus progression. PVT is not associated with increased risk of mortality. Optimal management has not been addressed in any consensus publication. We propose areas for future research to address unresolved clinical questions. 关键词：Portal vein THROMBOSIS Liver CIRRHOSIS ANTICOAGULATION Transjugular INTRAHEPATIC portosystemicstent-shunt

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Portal vein thrombosis in cirrhosis: Controversies and latest developments

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