Efficacy of Shenzhuo formula on diabetic kidney disease:a retrospective study

查看全文 作　　者：Tian [1,1,2]Jiaxing;Zhao [1]Linhua;Zhou [1]Qiang;Liu [1]Wenke;Chen [1]Xinyan;Lian [1]Fengmei;Tong [1]Xiaolin

机构地区：[1]Department of Endocrinology,Guang'anmen Hospital,China Academy of Chinese Medical Sciences;[2]Graduate School,Beijing University of Chinese Medicine

出　　处：《Journal of Traditional Chinese Medicine》索引2015年第35卷第5期,共9页

基　　金：Supported by the National Basic Research Program:the Basic Research of the Classical Prescription Basing on the Dose-Effect Relationship(973 Program;No.2010CB530601);the Special Fund for Traditional Chinese Medicine Scientific Research in the Public Interest:the Research,Application and Primotion of the Community-Based Traditional Chinese Medicine Treatment for Diabetes Mellitus(No.201007004) 摘　　要：OBJECTIVE:To observe the efficacy of a traditional Chinese medicine,Shenzhuo formula,on patients with diabetic kidney disease(DKD).METHODS:Eighty-eight outpatients with DKD were enrolled.Changes in estimated glomerular filtration rate(eGFR),creatinine clearance,serum creatinine,blood-urea-nitrogen,albuminuria,glycosylated hemoglobin(Hb_(A1C)),blood pressure,and lipid profile were measured and analyzed before and after intervention with Shenzhuo formula for 1,3,6,9,12,and 18 months.RESULTS:Compared with the baseline amounts,serum creatinine decreased,and eGFR and creatinine clearance increased,significantly after intervention for 1,3,6,9,12,and 18 months(all P < 0.05).Mean eGFR increased by 2.11 mL/min per 1.73 m7 y after18-month treatment.Urinary protein at 24 h decreased significantly after 1,3,9,and 12 months(P < 0.05).Hb_(A1C) decreased significantly(P < 0.05) after 3,6,9,12,and 18 months,and systolic blood pressure decreased significantly(P < 0.05) after 1,3,and 6 months.Total cholesterol decreased significantly(P < 0.05) after 1,3,6,and 18 months.Triglyceride and low-density lipoprotein-cholesterol decreased significantly(P < 0.05) after 1 and 3 months.CONCLUSION:Shenzhuo formula can improve eGFR and possibly slow DKD progression.Shenzhuo formula can also lower Hb_(A1C),lipid levels and blood pressure. 关键词：糖尿病肾病公式疗效低密度脂蛋白胆固醇肾小球滤过率 EGFR EGFR 总胆固醇

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Efficacy of Shenzhuo formula on diabetic kidney disease:a retrospective study

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