Insights into the mechanism of CXCL12-mediated signaling in trophoblast functions and placental angiogenesis

查看全文 作　　者：Liang [1,2]Wang;Xueyi [3]Li;Yilin [4]Zhao;Chao [5]Fang;Yingli [1]Lian;Wenli [6]Gou;Tao [7]Han;Xiaoming [1]Zhu

机构地区：[1]Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, China;[2]The First Student Brigade, The Fourth Military Medical University, Xi'an 710032, China;[3]Department of Clinical Immunology, PLA Specialized Research Institute of Rheumatism & Immunity, Xi-jing Hospital, The Fourth Military Medical University, Xi'an 710032, China;[4]Department of Respiratory Medicine, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China;[5]Institute of Neurosciences, School of Basic Medical Sciences, The Fourth Military Medical University, Xi'an 710032, China;[6]Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China;[7]Department of Orthopedics, Hainan Branch of PLA General Hospital, Sanya 572013, China

出　　处：《Acta Biochimica et Biophysica Sinica》索引2015年第47卷第9期,共10页

基　　金：This work was supported by the grants from the National Natural Science Foundation of China (Nos. 81471474, 31000660, and 81373200), the China Postdoctoral Science Foundation (Nos. 2014T70964 and 2013M532203), and Tangdu Hospital Reserve Per- sonnel Fund to X.Z. 摘　　要：chemokine CXCL12 和它的受体 CXCR4 是重要的表明为人的胚囊培植和怀孕的前进要求的部件。成长证据显示 CXCL12/CXCR4 轴能调整 trophoblast 功能和改变的子宫的螺线动脉,它在胎座式和胎儿的结果起一个基本作用。孤儿受体 CXCR7 也被相信部分调整 CXCL12/CXCR4 轴的功能。另外, CXCL12/CXCR4/CXCR7 轴能提高在象子宫的自然漂亮房间那样的 trophoblasts 和蜕膜的房间和涉及 trophoblast 区别和侵略和胎盘的 angiogenesis 的规定的蜕膜的 stromal 房间之间的串音。另外,最近的研究证明那 CXCL12 表情与 preeclampsia 在胎盘和怀孕女人的中间三个月的羊膜的液体被提高,暗示 CXCL12 的 dysregulation 起在 preeclampsia 的致病的一个作用。在 trophoblast 功能和胎盘的 angiogenesis 的调停 CXCL12 的发信号的规章的机制的进一步的理解可以帮助为联系怀孕的疾病设计新奇治疗学的途径。 关键词：血管生成细胞功能发病机制滋养层胎盘信号介导自然杀伤细胞

相关文献

参考文献（93）
引证文献（8）
耦合文献（0）

参考文献(93)

引证文献(8)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Insights into the mechanism of CXCL12-mediated signaling in trophoblast functions and placental angiogenesis

参考文献(93)

引证文献(8)

用户提示