Effect of acupuncture at Neiguan (PC 6) on cardiac function using echocardiography in myocardial ischemia rats induced by isoproterenol

查看全文 作　　者：Wang [1]Songzi;Ren [1]Lu;Jia [2]Lianqun;Gu [1]Zhongyue;Fan [1]Xu;Chen [2]Wenna;Hou [3]Ping;Liang [4]Fanrong;Rong [5]Peijing;Ma [1]Tieming;Liu [1]Xulai;Chen [1]Yiguo

机构地区：[1]Department of Acupuncture and Moxibustion,Liaoning University of Traditional Chinese Medicine;[2]Experimental Center,Liaoning University of Traditional Chinese Medicine;[3]Vasculocardiology Department,Liaoning Hospital of Traditional Chinese Medicine Affiliated to Liaoning University of Traditional Chinese Medicine;[4]Department of Acupuncture and Moxibustion,Chengdu University of Traditional Chinese Medicine;[5]Department of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences

出　　处：《Journal of Traditional Chinese Medicine》索引2015年第35卷第6期,共6页

基　　金：Supported by the Special Program of Chinese Medicine of the National Basic Research Program of China(973 Program):Study on the Response Characteristics of Cardiac Ion Channel to Acupuncture in Pathologic Conditions by Selecting Acupoint Along Channel(No.2012CB518503);Natural Science Fund of Liaoning Province:Study on the Effect of Acupuncture on the Neuroendocrine System and Calcium Channel Protein of Cardiomyocytes(No.2013020179);Shenyang Science and Technology Program:Study on the Influence on HDL Subclasses and RCT Pathway in apoE Knock Out Mice of Huayuqutan Reciple(No.F12-277-1-49) 摘　　要：OBJECTIVE: To investigate the effect of acupuncture at Neiguan(PC 6) on cardiac function using echocardiography in rat models of myocardial ischemia(MI) induced by isoproterenol(ISO).METHODS: Twenty-seven Sprague-Dawley rats were randomly assigned to normal, model, and acupuncture groups. The model and acupuncture groups were given injections of ISO(85 mg/kg) to establish the MI model. After model establishment,the acupuncture group was treated with acupuncture at Neiguan(PC 6) for 30 min. Echocardiography was used to monitor diastolic and systolic function for 30 min starting from the time after the acupuncture needles were removed. Changes in the length of left ventricular internal diameter at end-diastole(LVIDd), length of left ventricular internal diameter at end-systole(LVIDs), the ratio of mitral peak velocity at early diastole and atrial contraction(E/A), ejection fraction(EF), fractional shortening(FS), and stroke volume(SV) were measured.RESULTS: Compared with the model group at 0and 15 min after needles were removed, the means of LVIDd and LVIDs were significantly lower(P <0.01) and E/A, EF, FS, and SV significantly higher(P < 0.01) in the acupuncture group. In the acupuncture group, the means of LVIDd and LVIDs15 min after the needles were removed were significantly higher(P < 0.01) than those at 0 min. The means of E/A, EF, FS, and SV significantly decreased(P < 0.01) from 0 to 15 min in the acupuncture group.CONCLUSION: These findings indicate that acupuncture at Neiguan(PC 6) can affect cardiac function by increasing left ventricular diastolic and systolic function in MI rat models, but the effect only lasts for 15 min. 关键词：ACUPUNCTURE Point PC 6 (Neiguan) Myocardial ISCHEMIA Heart function tests Echocar-diography ISOPROTERENOL

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Effect of acupuncture at Neiguan (PC 6) on cardiac function using echocardiography in myocardial ischemia rats induced by isoproterenol

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