Current status and perspectives of immune-based therapiesfor hepatocellular carcinoma

查看全文 作　　者：Maridi [1]Aerts;[2]DaphnéBenteyn;Hans Van [3]Vlierberghe;Kris [2]Thielemans;Hendrik [1]Reynaert

机构地区：[1]Department of Gastroenterology and Hepatology,1090 Brussels,Belgium;[2]Vrije Universiteit Brussel(VUB),Department of Immunology,1090 Brussels,Belgium;[3]UZ Gent,Department of Gastroenterology and Hepatology,De Pinte laan,9000 Ghent,Belgium

出　　处：《World Journal of Gastroenterology》索引2016年第22卷第1期,共9页

基　　金：Supported by Grant from Kankerplan Action 29,Ministry of health,Belgium(to Aerts M);Van Vlierberghe H is senior researcher of the Flemish Fund for Research(FWO) 摘　　要：Hepatocellular carcinoma(HCC)is a frequent cancer with a high mortality.For early stage cancer there are potentially curative treatments including local ablation,resection and liver transplantation.However,for more advanced stage disease,there is no optimal treatment available.Even in the case of a'curative'treatment,recurrence or development of a new cancer in the precancerous liver is common.Thus,there is an urgent need for novel and effective(adjuvant)therapies to treat HCC and to prevent recurrence after local treatment in patients with HCC.The unique immune response in the liver favors tolerance,which remains a genuine challenge for conventional immunotherapy in patients with HCC.However,even in this'immunotolerant'organ,spontaneous immune responses against tumor antigens have been detected,although they are insufficient to achieve significant tumor death.Local ablation therapy leads to immunogenic tumor cell death by inducing the release of massive amounts of antigens,which enhances spontaneous immune response.New immune therapies such as dendritic cell vaccination and immune checkpoint inhibition are under investigation.Immunotherapy for cancer has made huge progress in the last few years and clinical trials examining the use of immunotherapy to treat hepatocellular carcinoma have shown some success.In this review,we discuss the current status of and offer some perspectives on immunotherapy for hepatocellular carcinoma,which could change disease progression in the near future. 关键词：HEPATOCELLULAR carcinoma IMMUNOTHERAPY DENDRITIC cells DENDRITIC cell VACCINATION Therapy

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Current status and perspectives of immune-based therapiesfor hepatocellular carcinoma

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