Liver transplantation in acute liver failure:A challengingscenario

查看全文 作　　者：Manuel [1]Mendizabal;Marcelo Oscar [1]Silva

机构地区：[1]Hepatology and Liver Transplant Unit,Hospital Universitario Austral,Pilar B1629AHJ,Argentina

出　　处：《World Journal of Gastroenterology》索引2016年第22卷第4期,共9页

摘　　要：Acute liver failure is a critical medical condition defined as rapid development of hepatic dysfunction associated with encephalopathy. The prognosis in these patients is highly variable and depends on the etiology, intervalbetween jaundice and encephalopathy, age, and the degree of coagulopathy. Determining the prognosis for this population is vital. Unfortunately, prognostic models with both high sensitivity and specificity for prediction of death have not been developed. Liver transplantation has dramatically improved survival in patients with acute liver failure. Still, 25% to 45% of patients will survive with medical treatment. The identification of patients who will eventually require liver transplantation should be carefully addressed through the combination of current prognostic models and continuous medical assessment. The concerns of inaccurate selection for transplantation are significant, exposing the recipient to a complex surgery and lifelong immunosuppression. In this challenging scenario, where organ shortage remains one of the main problems, alternatives to conventional orthotopic liver transplantation, such as living-donor liver transplantation, auxiliary liver transplant, and ABO-incompatible grafts, should be explored. Although overall outcomes after liver transplantation for acute liver failure are improving, they are not yet comparable to elective transplantation. 关键词：ENCEPHALOPATHY FULMINANT HEPATIC failure Liver transplantation OUTCOME PROGNOSTIC SCORE

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Liver transplantation in acute liver failure:A challengingscenario

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