Post reperfusion syndrome during liver transplantation:From pathophysiology to therapy and preventive strategies

查看全文 作　　者：Antonio [1]Siniscalchi;Lorenzo [1]Gamberini;Cristiana [1]Laici;Tommaso [1]Bardi;Giorgio [2]Ercolani;Laura [1]Lorenzini;Stefano [1]Faenza

机构地区：[1]Division of Anesthesiology,Alma Mater Studiorum University of Bologna,40138 Bologna,Italy;[2]Division of Surgery,Alma Mater Studiorum University of Bologna,40138 Bologna,Italy

出　　处：《World Journal of Gastroenterology》索引2016年第22卷第4期,共19页

基　　金：Supported by The Department of Anesthesiology of the University of Bologna 摘　　要：This review aims at evaluating the existing evidence regarding post reperfusion syndrome, providing a description of the pathophysiologic mechanisms involved and possible management and preventive strategies. A Pub Med search was conducted using the Me SH database, 'Reperfusion' AND 'liver transplantation' were the combined Me SH headings; EMBASE and the Cochrane library were also searched using the same terms. 52 relevant studies and one ongoing trial were found. The concept of post reperfusion syndrome has evolved through years to a multisystemic disorder. The implications of the main organ, recipient and procedure related factors in the genesis of this complex syndrome are discussed in the text as the novel pharmacologic and technical approaches to reduce its incidence. However the available evidence about risk factors, physiopathology and preventive measures is still confusing, the presence of two main definitions and the numerosity of possible confounding factors greatly complicates the interpretation of the studies. 关键词：Liver TRANSPLANTATION REPERFUSION Ischemiareperfusioninjury HEMODYNAMICS DRUG THERAPY

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Post reperfusion syndrome during liver transplantation:From pathophysiology to therapy and preventive strategies

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