Diagnosing gastrointestinal illnesses using fecal headspacevolatile organic compounds

查看全文 作　　者：Daniel K [1]Chan;Cadman L [1]Leggett;Kenneth K [1]Wang

机构地区：[1]Division of Gastroenterology and Hepatology,Mayo Clinic,Rochester,MN 55905,United States

出　　处：《World Journal of Gastroenterology》索引2016年第22卷第4期,共11页

基　　金：Supported by National Institute of Health Grants;No.P30 CA015083;No.U01 CA182940;No.U54 CA163004;Kathy and Russ Van Cleve Endowment for Gastroenterology Research(all to Wang KK) 摘　　要：Volatile organic compounds(VOCs) emitted from stool are the components of the smell of stool representing the end products of microbial activity and metabolism that can be used to diagnose disease. Despite the abundance of hydrogen, carbon dioxide, and methane that have already been identified in human flatus, the small portion of trace gases making up the VOCs emitted from stool include organic acids, alcohols, esters, heterocyclic compounds, aldehydes, ketones, and alkanes, among others. These are the gases that vary among individuals in sickness and in health, in dietary changes, and in gut microbial activity. Electronic nose devices are analytical and pattern recognition platforms that can utilize mass spectrometry or electrochemical sensors to detect these VOCs in gas samples. When paired with machine-learning and pattern recognition algorithms, this can identify patterns of VOCs, and thus patterns of smell, that can be used to identify disease states. In this review, we provide a clinical background of VOC identification, electronic nose development, and review gastroenterology applications toward diagnosing disease by the volatile headspace analysis of stool. 关键词：Electronic NOSE VOLATILE organic compounds FECES Mass spectrometry Odors

相关文献

参考文献（76）
引证文献（5）
耦合文献（0）

参考文献(76)

引证文献(5)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Diagnosing gastrointestinal illnesses using fecal headspacevolatile organic compounds

参考文献(76)

引证文献(5)

用户提示