Portopulmonary hypertension in liver transplant candidates

查看全文 作　　者：Serife Savas [1]Bozbas;Huseyin [2]Bozbas

机构地区：[1]Department of Pulmonary Disease,Baskent University Faculty of Medicine,06490 Ankara,Turkey;[2]Cardiology Clinic,Guven Hospital,06540 Ankara,Turkey

出　　处：《World Journal of Gastroenterology》索引2016年第22卷第6期,共6页

摘　　要：Pulmonary vascular disorders including portopulmonary hypertension(PoPHT) are among the common complications of liver disease and are prognostically significant. Survival is very low without medical treatment and liver transplantation. With advances in medical therapy for elevated pulmonary artery pressure(PAP) and liver transplant surgery, survival of patients with Po PHT and advanced liver disease is significantly improved. Because of the prognostic significance of Po PHT and the limited donor pool, a comprehensive preoperative cardio-pulmonary assessment is of great importance in cirrhotic patients prior to transplant surgery. Therefore, a detailed transthoracic Doppler echocardiographic examination must be an essential component of this evaluation. Patients with mild Po PHT can safely undergo liver transplant surgery. In cases of moderate to severe Po PHT, right heart catheterization(RHC) should be performed. In patients with moderate to severe Po PHT on RHC(mean PAP 35-45 mm Hg), vasodilator therapy should be attempted. Liver transplantation should be encouraged in cases that demonstrate a positive response. Bridging therapy with specific pulmonary arterial hypertension treatment agents should be considered until the transplant surgery and should be continued during the peri- and post-operative periods as needed. 关键词：portopulmonary HYPERTENSION pulmonaryarterial HYPERTENSION LIVER DISEASE LIVER TRANSPLANTATION PORTAL HYPERTENSION

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Portopulmonary hypertension in liver transplant candidates

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