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MicroRNA in pancreatic ductal adenocarcinoma and its precursor lesions

查看全文 作　　者：yasmin g [1]hernandez;aimee l [2]lucas 高影响力作者 机构地区：[1]department of internal medicine,icahn school of medicine at mount sinai,New York,NY 10029,United States;[2]henry janowitz division of gastroenterology,icahn school of medicine at mount sinai,New York,NY 10029,United States高影响力机构 出　　处：《World Journal of Gastrointestinal Oncology》索引2016年第8卷第1期,共12页高影响力期刊 摘　　要：Pancreatic ductal adenocarcinoma(PDAC) is the 4^(th) deadliest cancer in the United States, due to its aggressive nature, late detection, and resistance to chemotherapy. The majority of PDAC develops from 3 precursor lesions, pancreatic intraepithelial lesions(PanIN), intraductual papillary mucinous neoplasm(IPMN), and mucinous cystic neoplasm. Early detection and surgical resection can increase PDAC 5-year survival rate from 6% for Stage Ⅳ to 50% for Stage Ⅰ. To date, there are no reliable biomarkers that can detect PDAC. MicroRNAs(miRNA) are small noncoding RNAs(18-25 nucleotides) that regulate gene expression by affecting translation of messenger RNA(mRNA). A large body of evidence suggests that miRNAs are dysregulated in various types of cancers. MiRNA has been profiled as a potential biomarker in pancreatic tumor tissue, blood, cyst fluid, stool, and saliva. Four mi RNA biomarkers(miR-21, miR-155, miR-196, and miR-210) have been consistently dysregulated in PDAC. MiR-21, miR-155, and miR-196 have also been dysregulated in IPMN and PanIN lesions suggesting their use as early biomarkers of this disease. In this review, we explore current knowledge of miRNA sampling, miR NA dysregulation in PDAC and its precursor lesions, and advances that have been made in using miRNA as a biomarker for PDAC and its precursor lesions. 关 键 词：PANCREATIC CANCER MICRORNA Biomarkers PANCREATIC intraepithelial LESIONS INTRADUCTAL papillarymucinous NEOPLASM
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