Synthesis, antibacterial and anti-inflammatory activity of bis(indolyl)methanes

查看全文 作　　者：Santhisudha [1]Sarva;Jayaprakash Soora [1]Harinath;Siva Prasad [1]Sthanikam;Selvarajan [2]Ethiraj;Mohanasrinivasan [2]Vaithiyalingam;Suresh Reddy [1]Cirandur

机构地区：[1]Department of Chemistry, Sri Venkateswara University;[2]School of Biosciences and Technology, VIT University

出　　处：《Chinese Chemical Letters》索引2016年第27卷第1期,共5页

基　　金：financial assistance through a Major Research Project (F. No. 42281/2013 (SR), Dated: 12-03-2013) 摘　　要：A series of bioactive bis(indolyl)methanes are synthesized by one-pot green reaction of indole with various substituted aldehydes by microwave irradiation under solvent free conditions. The antibacterial activity against Staphylococcus aureus and anti-inflammatory activity of the synthesized bis(indolyl)-methanes are evaluated in vitro and compared to standard drugs tetracycline and diclofenac,respectively. The majority of the compounds showed good antibacterial and anti-inflammatory activity.Interestingly, compounds 3j, 3i, 3k and 3g exhibited much higher anti-inflammatory activity than the standard diclofenac drug and thus qualify for clinical trials to be used as an anti-inflammatory compound. 关键词：化学化学原理化学方法化学元素

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Synthesis, antibacterial and anti-inflammatory activity of bis(indolyl)methanes

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