Bidirectional regulation of angiogenesis by phytoestrogens through estrogen receptor-mediated signaling networks

查看全文 作　　者：LIU Hai-[1,2]Xin;WANG [1,2]Yu;LU [3]Qing;YANG Ming-[1,2]Zhu;FAN Guan-[1]Wei;KARAS Richard [3]H;GAO Xiu-[1]Mei;ZHU [1,2,3]Yan

机构地区：[1]Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine;[2]Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology & Medicine;[3]Molecular Cardiology Research Institute, Tufts Medical Center

出　　处：《Chinese Journal of Natural Medicines》索引2016年第14卷第4期,共14页

基　　金：supported by National Natural Science Foundation of China(No.81274128);China National Funds for Distinguished Young Scientists(No.81125024);the Program of the State Key Development Program for Basic Research of China(No.2012CB723504) 摘　　要：Sex hormone estrogen is one of the most active intrinsic angiogenesis regulators; its therapeutic use has been limited due to its carcinogenic potential. Plant-derived phytoestrogens are attractive alternatives, but reports on their angiogenic activities often lack in-depth analysis and sometimes are controversial. Herein, we report a data-mining study with the existing literature, using IPA system to classify and characterize phytoestrogens based on their angiogenic properties and pharmacological consequences. We found that pro-angiogenic phytoestrogens functioned predominantly as cardiovascular protectors whereas anti-angiogenic phytoestrogens played a role in cancer prevention and therapy. This bidirectional regulation were shown to be target-selective and, for the most part, estrogen-receptor-dependent. The transactivation properties of ERα and ERβ by phytoestrogens were examined in the context of angiogenesis-related gene transcription. ERα and ERβ were shown to signal in opposite ways when complexed with the phytoestrogen for bidirectional regulation of angiogenesis. With ERα, phytoestrogen activated or inhibited transcription of some angiogenesis-related genes, resulting in the promotion of angiogenesis, whereas, with ERβ, phytoestrogen regulated transcription of angiogenesis-related genes, resulting in inhibition of angiogenesis. Therefore, the selectivity of phytoestrogen to ERα and ERβ may be critical in the balance of pro- or anti-angiogenesis process. 关键词：PHYTOESTROGEN Selective estrogen receptor modifies(SERMs) ERα ERΒ Bidirectional regulation of angiogenesis IPA

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Bidirectional regulation of angiogenesis by phytoestrogens through estrogen receptor-mediated signaling networks

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