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Central neuromechanisms underlying control of intragastric pressure through acupuncture at Zusanli(ST36) in rats: the upper cervical cord is the key link between the ascending and descending pathways

查看全文 作　　者：Chun-yan [1]Yong;Shu [2]Chen;Heng [2]Chen;Xiao [2]Chu;Chao [2]Zhang;Cheng [2]Tan;Lan [2]Ye;Jiang-shan [2]Li 高影响力作者 机构地区：[1]Department of Integrative Medicine, Xiangya Hospital of Central South University;[2]School of Acupuncture and Massage, Hunan University of Chinese Medicine高影响力机构 出　　处：《Neural Regeneration Research》索引2016年第11卷第6期,共6页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China,No.81273677;a grant from the Postgraduate Innovation Topics of Hunan University of Chinese Medicine in China in 2014,No.2014CX01 摘　　要：Sensory inputs stimulated by Zusanli(ST36) acupuncture in the abdomen are known to converge in the upper cervical cord. However, it is unclear whether these inputs are subsequently conveyed to the hypothalamic paraventricular nucleus and what kind of afferent fibers are involved. We focused on the upper cervical cord, where afferent inputs converge, and detected c-fos expression in oxytocinergic neurons. We found that Zusanli acupuncture therapy effectively elevated intragastric pressure, but inhibited expression of c-fos in oxytocinergic neurons of the paraventricular nucleus in upper cervical cord injured rats. These Zusanli acupuncture effects remained even after complete dorsal cord transection. However, after complete transection of the spinal cord or dorsolateral funiculus, the effects were significantly attenuated and even disappeared. These findings suggest that the paraventricular nucleus is responsible for pooling and integrating signals from the Zusanli acupuncture and sensory information from the intragastric pressure variation, thereby contributing to the regulation of intragastric pressure. The upper cervical cord serves as the key link between ascending and descending pathways, which conveys afferent inputs to the paraventricular nucleus through the dorsolateral funiculus. 关 键 词：针刺疗法 内压力 颈髓 通路 大鼠 下丘脑室旁核 c-fos 胃
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