Enhanced Anti-corrosion Ability and Biocompatibility of PLGA Coatings on MgZnYNd Alloy by BTSE-APTES Pre-treatment for Cardiovascular Stent

查看全文 作　　者：Jing [1]Liu;Tingfei [1,2]Xi

机构地区：[1]Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University;[2]Shenzhen Institute, Peking University

出　　处：《Journal of Materials Science & Technology》索引2016年第32卷第9期,共13页

基　　金：the financial support from the National Basic Research Program of China (Grant No. 2012CB619102);the Shenzhen Special Funds for Development of Strategic Emerging Industries (Project No. JCYJ20130402172114948);the Shenzhen Science and Technology Funding Projects (No. CXZZ20140730091722497);the Natural Science Foundation of Guangdong Province, China (No. 2016A030310245, No. 2016A030310244) 摘　　要：Bioabsorbable magnesium alloys are widely studied for various implant applications, as they reduce the risks such as severe inflammatory response existing in permanent metallic implants. However, the overfast corrosion rate of magnesium alloy is usually an obstacle in biomedical applications. Here we report a simple two-step reaction to introduce anticorrosive silane pre-treatment on Mg Zn YNd alloys before coating with poly(glycolide-co-lactide)(PLGA). The first step is to immerse the NaO H-activated MgZ nY Nd with bistriethoxysilylethane(BTSE) to form a cross-linked silane coating layer with enhanced corrosion resistance; the second step involves immobilizing amine functional groups for forming hydrogen bond with outer PLGA coating by treating the BTSE-modified MgZnYNd with 3-amino-propyltrimethoxysilane(APTES). We characterized the BTSE-APTES pre-treated PLGA coating on MgZnYNd by scanning electron microscopy(SEM), Fourier transform infrared spectroscopy(FT-IR), X-ray photoelectron spectroscopy(XPS),static contact angle and Acid Orange 7 measurement. Nano-scratch test was to verify that the scratch resistance of the PLGA coating with BTSE-APTES pre-treatment was superior to direct PLGA coating. Standard electrochemical measurements along with the long-term immersion results indicated that the BTSEAPTES pre-treatment rendered better in vitro degradation behavior. Cell adhesion and cell viability tests with both vascular smooth muscle cells(VSMC) and human umbilical vein endothelial cells(EA. hy926)demonstrated that BTSE-APTES pre-treated MgZnYNd substrate had significantly more beneficial effects.The favorable anti-corrosion behavior and biocompatibility of BTSE-APTES pre-treated PLGA coatings on MgZnYNd alloy suggest that the novel two-step silanization procedure may have the great potential to enhance the performance of the magnesium-based biomaterials and provide a valid solution for the conversion modification of cardiovascular implants, taking the magnesium-based bioabsorbable materials closer to clinical application. 关键词：生物相容性合金涂层 PLGA 预处理镁合金抗腐蚀能力血管支架人脐静脉内皮细胞

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Enhanced Anti-corrosion Ability and Biocompatibility of PLGA Coatings on MgZnYNd Alloy by BTSE-APTES Pre-treatment for Cardiovascular Stent

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