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Effect of treatment course of comprehensive intervention with Traditional Chinese Medicine on mortality of acquired immunodeficiency syndrome patients treated with combined antiretroviral therapy

查看全文 作　　者：Guo [1]Huijun;Wang [2]Jian;Li [1]Zhengwei;Jiang [1]Ziqiang;Xu [1]Qianlei;Xu [1]Liran 高影响力作者 机构地区：[1]Department of Acquired Immune Deficiency Syndrome AIDS Treatment and Research Center,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine;[2]Traditional Chinese Medicine Center for Acquired Immune Deficiency Syndrome Prevention and Treatment,China Academy of Traditional Chinese Medicine高影响力机构 出　　处：《Journal of Traditional Chinese Medicine》索引2016年第36卷第4期,共7页高影响力期刊 基　　金：Supported by Research Project for Practice Development of National Traditional Chinese Medicine Clinical Research Bases:Evaluation of the clinical effect of Acquired Immune Deficiency Syndrome Acquired Immunodeficiency Syndrome(AIDS)patients treated with Traditional Chinese Medicine in Henan province between 2004 and 2012(No.JDZX2012035);National Special Science and Technology Program on Major Infectious Diseases(No.2013ZX10005010-001);Special of Scientific Research of Traditional Chinese Medicine of Henan Province in China(No.2015ZY02097) 摘　　要：OBJECTIVE:To investigate the effect of a treatment course of comprehensive intervention with Traditional Chinese Medicine(TCM) on the mortality of patients with acquired immunodeficiency syndrome(AIDS) treated with combined antiretroviral therapy(c ART).METHODS:AIDS patients who had taken c ART in a national TCM human immunodeficiency virus treatment trial program(NTCMTP) before 2009 were enrolled in this study and followed for 36 months from November 2009.Patients enrolled in the NTCMTP in 2004 were taken as the first group,those enrolled in 2006 as the second group,and those enrolled in 2009 as the third group.Cumulative survival rates were calculated by the life table method.Survival curves for subgroups were compared by the log-rank test.Hazard ratios were calculated with a Cox proportional hazards model.RESULTS:A total of 1443 AIDS patients were followed for 3 years(4198 person-years).During this period,91(6.3%) patients died and 13(0.9%) were lost to follow-up.The total mortality rate was 2.17/100 person-years.The mortality rate of patients enrolled in the NTCMTP in 2004 was 1.49/100 person-years,which was lower than that of patients enrolled in 2006(2.23/100 person-years) and 2009(3.48/100 person-years).After adjusting for other factors,a shorter time of treatment with TCM,male sex,older age,lower CD4 + T-cell counts,and long-term treatment with c ART were risk factors of mortality.CONCLUSION:Long-term treatment with TCM decreased the mortality risk of AIDS patients.Factors such as being male,older age,CD4+ T-cell counts,and time of treatment with TCM and c ART were correlated with mortality. 关 键 词：Acquired immunodeficiency syndrome Antiretroviral therapy highly active MORTALITY MEDICINE Chinese traditional Retrospective cohort study
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