Zebrafish model for assessing induced organ toxicity by Strychnos nux-vomica

查看全文 作　　者：Zhao [1]Chongjun;Tian [1]Jinghuan;Wang [1]Jinfeng;Feng [1]Yaru;Ni [1]Yuanyuan;Fan [1]Jiaojiao;Wang [1]Chunmei;Cao [2]Dan;Zou [3]Qinwen;Ma [1]Zhiqiang;Lin [1]Ruichao

机构地区：[1]School of Chinese Materia Medica,Bejing University of Chinese Medicine,Beijing Key Laborator for Quality Evalution of Traditional Chinese Medicine;[2]New drug research and Development Department of Beijing Kowloon Pharmaceutical Co.,Ltd.;[3]Department of quality of control of Beijing lianxin Pharmaceutic Co.,Ltd.

出　　处：《Journal of Traditional Chinese Medicine》索引2016年第36卷第4期,共8页

基　　金：Supported by the Scientific Research And Postgraduate Education Joint Project(Key Technology Research and Application of Safety Evaluation for Toxic Chinese Medicinal Materials on the Basis of the Characteristics of Chemical Composition and Zebrafish,No.2050205) 摘　　要：OBJECTIVE:To assess the acute organ toxicity of Strychnos nux-vomica with zebrafish model visually.METHODS:To assess acute toxicity,we initially determined the lethal concentration after Strychnos nux-vomica treatment for 24 h.Zebrafish was treated with five concentrations Strychnos nux-≦vo LC10 for 24 h,and the effects ofmica on morphology,function of heart,central nervous system,liver,kidney and organ-specific cell death were assessed.Next,we assessed the reversibility of toxic effect.RESULTS:Strychnos nux-vomica has an effect on the different organs of zebrafish,including heart,central nervous system,liver,and kidney,and cadiotoxicity induced by Strychnos nux-vomica was reversible to some extent.CONCLUSION:Zebrafish model is suitable for confirming the toxic target organs for Chinese traditional medicine. 关键词：ZEBRAFISH Strychnos nux-vomica TOXICITY

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Zebrafish model for assessing induced organ toxicity by Strychnos nux-vomica

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