Sirtuin 5:a review of structure,known inhibitors and clues for developing new inhibitors

查看全文 作　　者：Lingling [1]Yang;Xiaobo [1]Ma;Yanying [1]He;Chen [1]Yuan;Quanlong [1]Chen;Guobo [2]Li;Xianggui [1]Chen

机构地区：[1]College of Food and Bioengineering,Xihua University;[2]Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education,West China School of Pharmacy,Sichuan University

出　　处：《Science China(Life Sciences)》索引2017年第60卷第3期,共8页

基　　金：supported by the Chun hui of Ministry of Education Project(Z2015120);the National Natural Science Foundation of China(81502989);the China Postdoctoral Science Foundation Funded Project(2015M570789) 摘　　要：Sirtuins(SIRTs) are nicotinamide adenine dinucleotide(NAD^+)-dependent protein deacetylases,which regulate important biological processes ranging from apoptosis,age-associated pathophysiologies,adipocyte and muscle differentiation,and energy expenditure to gluconeogenesis.Very recently,sirtuin 5(SIRT5) has received considerable attention due to that it was found to have weak deacetylase activity but strong desuccinylase,demalonylase and deglutarylase activities,and it was also found to be associated with several human diseases such as cancer,Alzheimer's disease,and Parkinson's disease.In this review,we for the first time summarized the structure characteristics,known peptide and small-molecule inhibitors of SIRT5,extracted some clues from current available information and introduced some feasible,practical in silico methods,which might be useful in further efforts to develop new SIRT5 inhibitors. 关键词：抑制剂结构开发烟酰胺腺嘌呤二核苷酸去乙酰化酶审查阿尔茨海默病生物过程

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Sirtuin 5:a review of structure,known inhibitors and clues for developing new inhibitors

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引证文献(8)

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