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Ocular manifestation and their associated factors among HIV/AIDS patients receiving highly active antiretroviral therapy in Southern Ethiopia

查看全文 作　　者：Anteneh [1]Amsalu;Kindie [2]Desta;Demiss [3]Nigussie;Demoze [2]Delelegne 高影响力作者 机构地区：[1]Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar P.O.box 196, Ethiopia;[2]School of medicine, College of Medicine and Health Sciences,Hawassa University, Hawassa EO.box 1560, Ethiopia;[3]Department of Medical Laboratory Science, College of Medicine and Health Sciences, Hawassa University, Hawassa RO.box 1560, Ethiopia高影响力机构 出　　处：《International Journal of Ophthalmology(English edition)》索引2017年第10卷第5期,共6页高影响力期刊 基　　金：the Hawassa University for financial support 摘　　要：AIM:To assess the pattern of ocular manifestation and associated factors among human immunodeficiency virus(HIV)/acquired immunodeficiency syndrome(AIDS) patients on highly active antiretroviral therapy(HAART) at Hawassa University Referral Hospital, Southern Ethiopia. METHODS:A cross sectional study was conducted from January 2014 to April 2015. After obtaining informed written consent, 240 adult HIV/AIDS patients on HAART were randomly selected regardless of their ophthalmic symptoms, WHO status or CD4 count. Data were collected using structured questionnaires and ophthalmologic clinical examination. Data were entered and analyzed using SPSS version 20.0 software. RESULTS:The mean duration of HAART was 62.5mo. The prevalence of HIV related ocular manifestation was 14.2%. Seborrheic blepharitis(5%) was the most common ocular manifestation, followed by squamoid conjunctival growth(3.8%). The rate of ocular manifestation was significantly higher among study participants who had CD4+ count <200 cells/μL(AOR=3.83; 95%CI:1.315-11.153), low duration of HAART(AOR=3.0; 95%CI:1.305-6.891) and who had primary school education [odds ratio(OR) =2.8; 95%CI:1.105-7.099]. Prevalence of visual impairment and blindness was 10.9% and 5.8%, respectively.CONCLUSION:HAART may be the reason for the decline in the prevalence of ocular manifestation in HIV/AIDS patients in the study area. Ophthalmologic screening of HIV/AIDS patients, especially those with CD4 counts of <200/μL cells and in the first five years of HAART followup is recommended to reduce visual impairment and/or blindness. 关 键 词：人的免疫不全病毒 获得的免疫不全症候群 眼睛的表明 高度活跃的 antiretroviral 治疗
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