Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA

查看全文 作　　者：Iain [1]M.Dykes;Costanza [1,2]Emanueli

机构地区：[1]School of Clinical Sciences,University of Bristol;[2]National Heart and Lung Institute,Imperial College London

出　　处：《Genomics, Proteomics & Bioinformatics》索引2017年第15卷第3期,共10页

基　　金：provided by the British Heart Foundation,UK(Grant No.CH/15/1/31199) 摘　　要：Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated.Much of the newly-discovered transcriptome appears to represent long non-coding RNA(lncRNA),a heterogeneous group of largely uncharacterised transcripts.Understanding the biological function of these molecules represents a major challenge and in this review we discuss some of the progress made to date.One major theme of lncRNA biology seems to be the existence of a network of interactions with microRNA(miRNA) pathways.lnc RNA has been shown to act as both a source and an inhibitory regulator of mi RNA.At the transcriptional level,a model is emerging whereby lnc RNA bridges DNA and protein by binding to chromatin and serving as a scaffold for modifying protein complexes.Such a mechanism can bridge promoters to enhancers or enhancer-like non-coding genes by regulating chromatin looping,as well as conferring specificity on histone modifying complexes by directing them to specific loci. 关键词：转录后非编码RNA 基因调控 MICRORNA 基因组学技术非编码RNA 生物学功能 miRNA

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Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA

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